COCONUT OIL IN HEALTH AND DISEASE: ITS AND MONOLAURIN’S
POTENTIAL AS CURE FOR HIV/AIDS*
By
Dr. Conrado S. Dayrit**
* Read at the XXXVII Cocotech Meeting Chennai, India. July 25, 2000
** Emeritus Professor of Pharmacology University of the Philippines
Past President. Federation of Asian Scientific Academies and Societies
Past President, National Academy of Science and Technology. Philippines
ABSTRACT
The coconut is called the tree of life for it has been providing us, humans, food and drink,
materials for housing, fuel and many industrial uses. And its medicinal uses are many and varied.
The latest medical potential of products of the coconut first identified by Jon Kabara and others in
the 70s, is the anti-bacterial, anti-viral and anti-fungal activity of its medium chain fatty acids,
particularly lauric acid (C12:0) in its monoglyceride form (monolaurin or ML).
The first clinical trial ever of ML was on 15 HIV-infected patients reporting regularly at the San
Lazaro Hospital, Manila who, never having received any anti-HIV medication, were randomly
assigned to 3 treatment groups: 7.2 g ML, 2.4 g ML and 50 ML of coconut oil daily for 6 months.
The San Lazaro Hospital Team was led by Eric Tayag.
Viral, CD4 and CDS counts, complete blood counts, blood lipids and tests for liver and kidney
functions were done at the beginning of the study and after 3 and 6 months of treatment. In one
patient, the viral load was too low to count.
By the 3rd month, 7 of the patients (50%) showed reduced viral load and by the 6th month 8
patients (2 receiving 7.2h ML, 4 receiving 2.4 g ML and 3 receiving, coconut oil had a lowered viral
count. The CD4/CD8 counts showed a favorable increase in 5 patients. There were no serious side
effects observed.
Three patients developed AIDS on 3rd month of therapy when their CD4 count dropped below
200. One of these three, who was in the coconut oil group. died 2 weeks after the study. The two other AIDS patients were in the 2.4 g ML group; one recovered fully on the 6th month and the other showed a rapid return towards normal CD4 and CD8 counts.
Introduction
Folkloric and Ayurvedic writings are replete with accounts of the efficacy of the coconut for
many ailments -from the cure of wounds, bums, ulcers, lice infestations to dissolution of kidney
stones(l) and treatment of choleraic dysenteries(2). The people of South Asia and the Pacific also
look to the coconut as an important provider of food, drink and fuel, not to mention its many uses in industry. Hence, it has been called the tree of life.
2
More recently, Lim-Sylianco et al demonstrated in animals a powerful protecting effect of
coconut oil against six powerful muta-carcinogenic chemicals, (such as benzpyrine, azaserine and
nitrosamines). The protection was observed not only when coconut oil was given with the diet for
several days before the mutacarcinogen but also when it was given in one bolus or dose with the
mutacarcinogen(J.4). In both experiments, coconut oil gave a significantly higher protection than
soybean oil. In another animal study by Lim-Navarro, et al (5), evidence for another protectant
effect of coconut oil was obtained, i.e. significant prevention against shock in rats injected with E.
coli endotoxin. The mechanism for these anti-inflammatory, antitoxic, antimutacarcinogenic actions
are still not known.
Anti-Infective Action
In a series of papers published in the 70s, Jon J Kabara et al (6-10) and other workers studied
the anti-microbial activity of various fatty acids. They found that the medium chain fatty acids
(MCF A) with 6 to 12 carbons, possessed significant activity against gram positive bacteria, but not
against gram negatives; they were also active against lipid coated viruses as well as fungi and
protozoa. Saturated fatty acids, longer than 14 carbons long had no such activity. And of the MCFA, lauric acid (CI2:0) was most potent, particularly in its monoglyceride form (monolaurin); it was more active than caprilic acid (C-
caprie acid (C-I0) or myristic acid (C-14). The dilaurin and
trilaurin (di and triglycerides) had no activity. This finding has found use in the incorporation of
monolaurin in cosmetic products and mouth washes; but although classified by the USFDA as
GRAS (Generally Regarded as Safe), its oral use for systemic inflections has not been tried.
HIV-AIDS Patients and the Coconut
According to Mary Enig(11), the AIDS organization, Keep Hope Alive, has documented several
HIV -AIDS patients whose viral load fell to as low as undetectable levels, when they took coconut
oil or ate coconut (half a coconut a day) or when they added coconut to their anti-HIV medication
(anti protease and/or antiretrovirals) that had previously not been effective. The amount of coconut oil consumed (50 ml or 3 1/2 tablespoonfuls) or half of a coconut, would contain 20-25 grams of lauric acid, which indicates that the oil is metabolized in the body to release lauric acid and/or monolaurin.
The Monolaurin Trial on HIV-AIDS
The first clinical trial (pilot study) using Monolaurin for 6 months as monotherapy on 15 mv
patients was just completed (12). These 15 patients (Table 1) ages 21 to 38 years, 5 males and 10 females, were all regularly reporting to San Lazaro Hospital, the hospital for infectious disease of
the Department of Health. None of them could afford’ or ever received anti-HIV treatment. The
males averaged 58 k in weight (49 to 68 k) and the females, 54k (39 to 65 k). Seven showed
elevated liver enzymes (ALT and AST) and 12 had unexplained eosinophilia. Two patients had
high serum cholesterol and one had elevated triglyceride. No one had renal dysfunction. Their viral
load ranged from 1,960 to 1,190,000 except for one patient (#94-022B) whose load was too low to 3 count (below 400). This fact unfortunately was not determined before the random assignment of the patients to the 3 treatment groups. The monolaurin used was 95% pure. It was given in capsules, each containing 800 mg ML. The coconut oil was administered by tablespoonfuls.
The 3 treatment groups to which the 15 patients were randomly assigned were {Table II):
a) High Dose Monolaurin (HML): 7.2 grams (9 capsules) ML 3 time daily or about
22 grams daily
b) Low Dose Monolaurin (LML): 2.4 grams (3 capsules) ML 3 times daily or 7.2
grams daily.
c) Coconut oil (CNO): 15 ml 3 times daily or 45 ml daily. The ML content of this
dose is about the same as HML.
All patients were observed daily for any side effects. Baseline, 3-month and 6-month laboratory
examinations included: viral load (by PCR method), CD4 and CD8 counts (by-flow-cytometric
method), complete blood count, tests for liver function (ALT, AST), renal function (urea N and
creatinine), blood lipids (cholesterol, triglycerides, HDL) and body weight (k). Treatment benefit
was defmed as reduction in viral load and increase in CD4 count.
Tables II and III summarize the effects of the 3 treatment groups on the viral load, CD4 and
CD8 counts. On the 3rd month, 2 showed decreased viral count with HML, 2 with LML and 3 with
CNO for a total of 7 patients benefited. The other patients all had increased viral load. Patient #94-
022A continued to have undeterminable viral load and was excluded from the computation. On the 6th month, and end of the study. 8 of the 14 patients had decreased viral count, (2 of the 4 given HML, 4 of the 5 given LML and 3 of the 5 given CNO). The decrease in viral count was, however, significant only in 3 patients using the log Baseline-log 6th month ~ 0.5 criterion. Two of these significant decreases were in the CNO group and one in the LML group.
The CD4. and CD8 counts (Table III) increased only in 5 patients and did not quite correlate
with the fall in viral load, decreasing even when the viral load fell and increasing when the viral
load rose. Patient #93006 had a steady viral load during the first 3 months but suffered a severe
secondary infection in the 5th and 6th month, which caused the HIV infection to worsen despite
fairly good CD4/CD8 response.
AIDS (CD4 less than 200) developed in 3 patients on the 3ni month of LML therapy (2 patients)
and CNO therapy (1 patient). The last mentioned patient (#86-001) died 2 weeks after the termination
of the study. The patient under LML, however, fared better; one (# 93028) recovered by the 6th
month. and the other (#95052) was showing improvement of both CD4 and CD8 counts at the end
of the study.
Eleven (11) subjects gained weight -from 1 k to 23 k -including the 2 who developed AIDS and
were recovering. The single AIDS fatality lost 6 k. The other 3 who failed to gain weight had
decreasing viral and rising CD4 counts.
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About one-half of the subjects in this study complained of feeling of warmth and a greenish
hue to their urine (Table IV A), Both occurred at the beginning of the study and did not interfere
with its continuation. Another 3 subjects had flaring up of their acne.
There were 11 subjects with eosinophilia at the start and 7 subjects with some liver dysfunction
(Table 1). The treatment caused a rise of the eosinophilia in 7 of the II, and a rise in ALT/AST in 3
of the 7 (Table IVA).
The patients with normal liver and kidney functions showed no effect from the treatments.
At the beginning, 2 subjects had elevated cholesterol and another one had high serum triglyceride
(Table !VB). After 6 months, 4 patients had abnormal cholesterol and triglyceride, 3 had high
cholesterol only and 2 had high triglyceride only.
Conclusion from the Study
This initial trial confirmed the anecdotal reports that coconut oil does have an anti-viral effect
and can beneficially reduce the viral load of HIV patients. The positive anti-viral action was seen
not only with the monoglyceride of lauric acid but with coconut oil itself. This indicates that coconut
oil is metabolized to monoglyceride forms of C-8, C-IO, C- 12 to which it must owe its antipathogenic
activity.
More and longer therapies using monolaurin will have to be designed and done before the
defmitive role of such coco products can be determined. With such products, the outlook for more
efficacious and cheaper anti HIV therapy is improved.
Anti-pathogen Mechanism of Monotriglycerides of MCT
The fact dlat monolaurin’s activity is limited to lipid coated organisms (gram positive bacteria,
enveloped viruses) suggests strongly that the relatively short C-12, C-IO or C-8 [Icelandic scientists
have recently reported on the effectiveness of monocaprin (C-IO) against HIV virus] probably exert
their action on the lipid-layered coat or plasma membrane to destabilize it or even to cause its
rupture. If this mechanism proves correct, monolaurin (and monocaprin and monocapryliu) could
be bactericidal and could act synergistically with the present anti-HIV agents (the antiretrovirals
and protease inhibitors).
Reprise
With all the opprobrium cast against it, it bears repeating again and again that no evidence has
ever been presented to prove that coconut oil causes coronary heart disease in humans. All the
evidences presented have been in various species of animals who were given coconut oil alone
without the necessary dose of essential fats or PUFA that should be given, just like the essential
vitamins and minerals. On the contrary, the human epidemiologic evidence proves that coconut oil
is safe. Coconut eating peoples like the Polynesians (Table V) and Filipinos (Fig. I) have low
cholesterol, on the average, and very low incidence of heart disease.
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