Juan M. Zavala-Rodriguez et al.
Departamento de Posgrado e Investigacion, Instituto Politecnico Nacional, Escuela Superior de Medicina, Mexico City, Mexico
Surgically induced adhesions complicate up to 100% of abdominal surgeries. Food and Drug Administration–approved treatments are generally not only less effective than desired but they also have major contraindications. Oxychlorine species, including chlorine dioxide (ClO2), suppress scar formation in infected wounds without affecting keratinocytes while reducing fibroblast proliferation. The aim of the present study was to evaluate the effect of oxychlorine solutions containing ClO2 on adhesion formation.
Male Wistar rats were subjected to Buckenmaier model of surgical adhesions and treated with either oxychlorine solutions containing ClO2 (40–150 ppm) or isotonic saline solution. To increase the severity of adhesions, peritonitis was produced by intraperitoneal administration of a diluted nonlethal dose of feces (50 mg/kg). Wound strength of the healed wound was measured to evaluate the effects of oxychlorine solutions. In addition, an oxychlorine solution of lesser efficacy (at 100 ppm) was compared with three available anti-adhesion materials.
Reproducibility of the model was validated in 26 rats. Oxychlorine solutions containing ClO2 (40–110 ppm) significantly reduced postsurgical adhesion formation without affecting the strength of the healed wound. Higher concentrations (120 and 150 ppm) had no effect. Fecal peritonitis significantly increased, and solutions with ClO2 at 110 ppm significantly reduced adhesion formation. The effect of the oxychlorine solution was significantly greater than that of Interceed, Guardix, Seprafilm, and isotonic saline solution.
Conclusions ClO2-containing oxychlorine solutions could be an innovative strategy for the suppression of surgical adhesion formation, with the additional advantage of contributing antiseptic properties.
are fibrous bands that form between tissues and organs, often as a result of injury during surgery. They may be thought of as internal scar tissue that connect tissues not normally connected.
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The following user(s) said Thank You: Truthquester, fourfingerz, JB13
I tend to produce scarring (keloids) whenever I have incisions - whether surgery or not, whether infected or not. The only time I haven't scarred is lately when I've used straight CDS on the wounds - and the healing time was greatly reduced, too.
Archbishop - Genesis II Church of Health and Healing - Washington State
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