In his latest version of the protocol/book, here is what it said regarding your question: "I began to realize that taking smaller doses of MMS1 more often throughout the day brought better results. Perhaps the most important reason for this is because MMS1 only lasts in your system for an hour, possibly an hour and a half at most. So keeping MMS1 running through your system on an hourly basis is imperative. This way MMS1 is hitting the pathogens continuously and does not allow pathogens time to regroup and build back up. Instead, being constantly hit without a chance to regroup, they die off. This new method works and we clearly see positive results"